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首页> 外文OA文献 >A Comparison of the Effectiveness of Sodium Stibogluconate Monotherapy to Sodium Stibogluconate and Paromomycin Combination for the Treatment of Severe Post Kala Azar Dermal Leishmaniasis in South Sudan - A Retrospective Cohort Study
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A Comparison of the Effectiveness of Sodium Stibogluconate Monotherapy to Sodium Stibogluconate and Paromomycin Combination for the Treatment of Severe Post Kala Azar Dermal Leishmaniasis in South Sudan - A Retrospective Cohort Study

机译：葡萄糖酸钠单独治疗牛磺酸钠和巴罗霉素联合治疗南苏丹重度卡拉阿扎尔真皮利什曼病的疗效比较 - 回顾性队列研究

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摘要

Post-kala-azar dermal leishmaniasis (PKDL) is a common dermatological complication following successful treatment of Visceral Leishmaniasis (VL) caused by Leishmania donovani. PKDL presents as macular, papular, nodular or mixed skin rash on sun-exposed body parts. Patients are not ill unless there are complications due to mucosal involvement or ulceration. As PKDL in East Africa is typically self-healing, and treatment is long and with significant adverse events, only severe and complicated cases are treated. Studies to determine optimal treatment of PKDL are rare and based on small cohorts. Since 1989, Médecins Sans Frontières is treating severe PKDL within VL treatment programmes in South Sudan. Treatment was initially with sodium stibogluconate (SSG) monotherapy and since 2002 with a combination of SSG and paromomycin (PM). SSG monotherapy (20 mg/kg/day for a minimum of 30 days) was provided in primary health units, and the combination of PM (15 mg sulphate/kg/day for 17 days) plus SSG (30 mg/kg/day for a minimum of 17 days) was provided in secondary health facilities.
机译：黑热病后皮肤利什曼病（PKDL）是成功治疗由多形利什曼原虫引起的内脏利什曼病（VL）后的常见皮肤病并发症。 PKDL在阳光照射下的身体部位表现为黄斑，丘疹，结节或混合性皮疹。除非因粘膜受累或溃疡引起并发症，否则患者不会生病。由于东非的PKDL通常可以自愈，而且治疗时间长且伴有严重不良事件，因此仅治疗严重和复杂的病例。确定PKDL最佳治疗方法的研究很少，并且基于较小的队列研究。自1989年以来，无国界医生开始在南苏丹的VL治疗计划中治疗严重的PKDL。最初使用stibogluconate钠（SSG）单药治疗，自2002年起采用SSG和巴龙霉素（PM）联合治疗。在主要医疗单位提供SSG单一疗法（20 mg / kg /天，至少30天），将PM（15 mg硫酸盐/ kg /天，持续17天）与SSG（30 mg / kg /天，二级医疗机构提供了至少17天的时间）。

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